Preliminary study of in vitro drug permeation using a pumpless microfluidic platform

Preliminary study of in vitro drug permeation using a pumpless microfluidic platform

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A 3-layer microfluidic device is developed using an inexpensive and readily accessible printer with commercially available printing material, polylactic acid.In addition, to serve as a semi-permeable membrane in microfluidic chip, chitosan/polyvinyl Gift Cards alcohol (CS/PVA) membrane was prepared using an electrospinning process.Electrospun membrane was prepared from a mixed solution of 10% w/v of PVA and 2% w/v of CS.The obtained electrospun CS/PVA membrane showed water resistance with a swelling degree of 97-98%.Their morphology observed by field emission scanning electron microscopy revealed uniform and completely bead free structures at the CS/PVA volume ratio of 30/70, whereas at the volume ratio of 40/60 produced some bead structure.

The electrospun membrane was assembled into 3D printing microfluidic chip to preliminary evaluate the drug permeability.By comparing between two nano-copyright systems for curcumin, the nano-copyright with smaller particle size showed faster drug permeation than another one Bike Parts - Grips with larger particle size.The developed 3D printing microdevices can be utilized gravity as the driving force, allowing for preliminary drug permeation screening with small amount of sample.